Study: New vaccine to stop bovine TB developed
Researchers have developed a novel vaccine and complementary skin test to protect cattle against bovine tuberculosis (bovine TB). The study, published in the journal Scientific Reports, revealed that the research team from University of Surrey created a vaccine that is compatible with a synthetic form of the tuberculin skin test(PPD), a legally required test used for the surveillance of TB in cattle throughout the UK.
"This new vaccine provides protection against bovine TB and will help in the fight against this deadly disease which infects over 50 million cattle worldwide and is economically devastating to farmers," said study researcher Johnjoe McFadden. Bovine TB is an infectious disease in cattle affecting their lungs, and those that test positive for the disease are culled.
The Bacille Calmette Guerin (BCG) vaccine, which is currently used to protect humans against TB and is effective in cattle, is incompatible with the PPD test. During this study, researchers sought to make a new BCG vaccine strain that lacks some of the proteins that are shared with the pathogen Mycobacterium bovis by identifying genes that contain encoded immunogenic proteins that could be removed from BCG without affecting its ability to work as a live vaccine.