Study: Fertility in danger! Men try having family before it's too late

A study found that men who delay in starting a family can affect the health of their partners as well as the children in future. The study was published in the journal, 'Maturitas'. The study reviewed 40 years of research on the effect of parental age on fertility, pregnancy and the health of children. "While it is widely accepted that physiological changes that occur in women after 35 can affect conception, pregnancy and the health of the child, most men do not realise their advanced age can have a similar impact," said Gloria Bachmann, the lead author of the research.

While the medical profession has not clearly accepted the definition of when does advanced paternal age begins, it ranges from 35 to 45. Infants born to fathers over 45 have risen 10 per cent in the United States over the past 40 years, likely due to assisted reproductive technology. The study found that men who are 45 and above can experience decreased fertility and put their partners at risk for increasing pregnancy complications such as gestational diabetes, preeclampsia and preterm birth.

Infants born to older fathers were found to be at higher risk of premature birth, late stillbirth, low Apgar scores, low birth weight, higher incidence of newborn seizures and birth defects such as congenital heart disease and cleft palate. As they get mature, these children were found to have an increased likelihood of childhood cancers, psychiatric and cognitive disorders and autism. Bachmann attributes most of these outcomes to a natural decline in testosterone that occurs with ageing, as well as sperm degradation and poorer semen quality, but she said that some correlations need more research.

"In addition to advancing paternal age being associated with an increased risk of male infertility, there appear to be other adverse changes that may occur to the sperm with ageing. For example, just as people lose muscle strength, flexibility and endurance with age, in men, sperm also tends to lose 'fitness' over the life cycle," she said.

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